Recent Publications

• Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity
  November 3, 2024
• 2,3,7,8-Tetrachlorodibenzo-<em>p</em>-dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression
  November 1, 2024
• Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure
  August 28, 2024
• Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice
  November 28, 2023
• Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity
  October 3, 2023
• Generative modeling of single-cell gene expression for dose-dependent chemical perturbations
  August 21, 2023
• A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data
  June 23, 2023
• Cystine/Glutamate Xc^- Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-<em>p</em>-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis
  May 15, 2023
• Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
  March 14, 2023
• A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds
  November 24, 2022
• Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
  October 12, 2022
• Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup
  August 5, 2022
• Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver
  February 15, 2022
• Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs
  January 21, 2022
• Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-<em>p</em>-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease
  November 27, 2021

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