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Articles

2013

  • Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature ovariectomized C57BL/6 mice. Toxicol Sci. 2013. Jul [epub ahead of print].
  • Kim S, Kiyosawa N, Burgoon LD, Chang CC, Zacharewski TR. PPARα-mediated responses in human adult  liver stem cells: in vivo/in vitro and cross-species comparisons. J Steroid Biochem Mol Biol. 2013 Jun 27;138C:236-247.
  • Forgacs AL, D'Souza ML, Huhtaniemi IT, Rahman NA, Zacharewski TR. Triazine herbicides and their chlorometabolites alter steroidogenesis in BLTK1 murine Leydig cells. Toxicol Sci. 2013 Jul;133(1):155-67.
  • Forgacs AL, Dere E, Angrish MM, Zacharewski TR. Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse and rat primary hepatocytes. Toxicol Sci. 2013 May;133(1):54-66.
  • Nault R, Kim S, Zacharewski TR. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicol Appl Pharmacol. 2013 Mar;267(2):184-91.
  • Angrish MM, Dominici CY, Zacharewski TR. TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice. Toxicol Sci. 2013 Jan;131(1):108-15.
 

2012

  • Angrish MM, Mets BD, Jones AD, Zacharewski TR. Dietary fat is a source in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicol Sci. 2012 Aug;128(2):377-86.
  • Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. Toxicol Appl Pharmacol. 2012 Jul;262(2):124-38.
  • Forgacs AL, Ding Q, Jaremba RG, Huhtaniemi IT, Rahman NA, Zacharewski TR. BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants. Toxicol Sci. 2012 Jun;127(2):391-402.
  • Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol. 2012 Feb;259(1):13-26.
  • Forgacs AL, Kent MN, Makley MK, Mets B, DelRaso N, Jahns GL, Burgoon LD, Zacharewski TR, Reo NV. Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver. Toxicol Sci. 2012 Jan;125(1):41-55.

 

 

2011

  • Angrish MM, Jones AD, Harkema JR, Zacharewski TR. Aryl hydrocarbon receptor-mediated induction of stearoyl-coA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicol Sci. 2011 Dec;124(2):299-310.
  • Lo R, Celius T, Forgacs AL, Dere E, MacPherson L, Harper P, Zacharewski TR, Matthews J. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 2011 Nov 15;257(1):38-47.
  • Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicol Appl Pharm. 2011 Oct 15;256(2):154-67.
  • Dere E, Lo R, Celius T, Matthews J, Zacharewski TR. Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver. BMC Genomics. 2011 Jul 15;12:365.
  • Dere E, Lee AW, Burgoon LD, Zacharewski TR. Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells. BMC Genomics. 2011 Apr 15;12:193.
  • Dere E, Forgacs AL, Zacharewski T, Burgoon L. Genome-Wide Computational Analysis of Dioxin Response Element Location and Distribution in the Human, Mouse and Rat Genomes. Chem Res Toxicol. 2011 Mar 3.
 

2010

  • Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Potter D, Sharratt B, Harkema JR, Rowlands JC, Budinsky RA, Zacharewski TR. Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. Toxicol Sci. 2010 Nov;118(1):286-97.
  • Fong CJ, Burgoon LD, Williams KJ, Jones AD, Forgacs AL, Zacharewski TR. Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice. J Mol Endocrinol. 2010 Sep;45(3):161-73.
  • Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski T. Effects of TCDD on the expression of nuclear encoded mitochondrial genes. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):58-65.
  • Kopec AK, Burgoon LD, Ibrahim-Aibo D, Mets BD, Tashiro C, Potter D, Sharratt B, Harkema JR, Zacharewski TR. PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):359-71.
 

2009

  • Kwekel JC, Forgacs AL, Burgoon LD, Williams KJ, Zacharewski TR. Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program. BMC Med Genomics. 2009 Apr 28;2:19.
  • Burgoon LD, Ding Q, N'jai A, Dere E, Burg AR, Rowlands JC, Budinsky RA, Stebbins KE, Zacharewski TR. Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice. Toxicol Sci. 2009 Nov;112(1):221-8.
  • Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR. Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44.
 

2008

  • Boverhof, D. R., Burgoon, L. D., Williams, K. J., and Zacharewski, T. R. Inhibition of estrogen-mediated uterine gene expression responses by dioxin. Mol Pharmacol. 2008 Jan;73(1):82-93.
  • Burgoon, L. D., and Zacharewski, T. R. Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets. Toxicol Sci. 2008 Aug;104(2):412-8.
  • Burgoon, L. D., and Zacharewski, T. R. Bioinformatics: databasing and gene annotation. Methods Mol Biol. 2008;460:145-57.
  • Frericks, M., Burgoon, L. D., Zacharewski, T. R., and Esser, C. Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):268-79.
  • Kiyosawa, N., Kwekel, J. C., Burgoon, L. D., Dere, E., Williams, K. J., Tashiro, C., Chittim, B., and Zacharewski, T. R. Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. BMC Genomics. 2008 Oct 16;9:487.
  • Kiyosawa, N., Kwekel, J. C., Burgoon, L. D., Williams, K. J., Tashiro, C., Chittim, B., and Zacharewski, T. R. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Toxicol Sci. 2008 Feb;101(2):350-63.
  • Kopec, A. K., Boverhof, D. R., Burgoon, L. D., Ibrahim-Aibo, D., Harkema, J. R., Tashiro, C., Chittim, B., and Zacharewski, T. R. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci. 2008 Mar;102(1):61-75.
  • N'Jai, A., Boverhof, D. R., Dere, E., Burgoon, L. D., Tan, Y. S., Rowlands, J. C., Budinsky, R. A., Stebbins, K. E., and Zacharewski, T. R. Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice. Toxicol Sci. 2008 Jun;103(2):285-97.
 

2007

  • Burgoon, L. D., and Zacharewski, T. R. (2007). dbZach toxicogenomic information management system. Pharmacogenomics 8, 287-91.
  • Charles, G. D., Gennings, C., Tornesi, B., Kan, H. L., Zacharewski, T. R., Bhaskar Gollapudi, B., and Carney, E. W. (2007). Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison. Toxicology and applied pharmacology 218, 280-8.
  • Fong, C. J., Burgoon, L. D., Williams, K. J., Forgacs, A. L., and Zacharewski, T. R. (2007). Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. BMC genomics 8, 151.
 

2006

  • Boverhof, D. R., Burgoon, L. D., Tashiro, C., Sharratt, B., Chittim, B., Harkema, J. R., Mendrick, D. L., and Zacharewski, T. R. (2006). Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol Sci 94, 398-416.
  • Boverhof, D. R., Kwekel, J. C., Humes, D. G., Burgoon, L. D., and Zacharewski, T. R. (2006). Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus. Molecular pharmacology 69, 1599-606.
  • Boverhof, D. R., and Zacharewski, T. R. (2006). Toxicogenomics in risk assessment: applications and needs. Toxicol Sci 89, 352-60.
  • Burgoon, L. D., Boutros, P. C., Dere, E., and Zacharewski, T. R. (2006). dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol Sci 90, 558-68.
  • Dere, E., Boverhof, D. R., Burgoon, L. D., and Zacharewski, T. R. (2006). In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue. BMC genomics 7, 80.
  • Fong, C. J., Burgoon, L. D., and Zacharewski, T. R. (2006). Effects of culture conditions on estrogen-mediated hepatic in vitro gene expression and correlation to in vivo responses. Toxicology and applied pharmacology 215, 37-50.
  • Lee, K. A., Burgoon, L. D., Lamb, L., Dere, E., Zacharewski, T. R., Hogenesch, J. B., and LaPres, J. J. (2006). Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chemical research in toxicology 19, 1284-93.

 

2005

  • Burgoon, L.D., Eckel-Passow, J.E., Gennings, C., Boverhof, D.R., Burt, J.W., Fong, C.J., Zacharewski, T.R. (2005) Protocols for the Assurance of Microarray Data Quality and Process Control. Nucleic Acids Research. 33(19): e172 [PDF]
  • Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, Zacharewski TR. (2005) Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity. Toxicological Sciences. 85(2), 1048-1063. [PDF]
  • Fong, C.J., Burgoon, L.D., Zacharewski, T.R. (2005) Comparative Microarray Analysis of Basal Gene Expression in Mouse Hepa-1c1c7 Wild-type and Mutant Cell Lines. Toxicological Sciences. 86(2), 342-353. [PDF] [Supplementary Data]
  • Eckel J.E., Gennings C., Therneau T.M., Burgoon, L.D., Boverhof D.R., Zacharewski T.R. (2004) Normalization of Two-Channel Microarray Experiments: A Semiparametric Approach. Bioinformatics. 21(7), 1078-1083. [PDF]
  • Kwekel, J. C., Burgoon, L. D., Burt, J. W., Harkema, J. R., and Zacharewski, T. R. (2005). A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling. Physiological genomics 23, 327-42. [PDF] [Supplementary Data]
  • Huang, Y. W., Matthews, J. B., Fertuck, K. C., and Zacharewski, T. R. (2005). Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Environmental toxicology and chemistry / SETAC 24, 2002-9.
 

2004

  • Eckel J.E., Gennings C., Chinchilli V.M., Burgoon L.D., Zacharewski T.R. (2004) Empirical Bayes gene screening tool for time-course or dose–response microarray data. Journal of Biopharmaceutical Statistics. 14(3), 647-670. [PDF]

  • Boverhof D.R, Tam E., Harney A.S., Crawford R.B., Kaminski N.E., Zacharewski T.R. (2004) 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. Molecular Pharmacology. 66, 1662-1670. [PDF]

  • Sun Y.V., Boverhof D.R., Burgoon L.D., Fielden M.R., Zacharewski T.R. (2004) Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Research. 32(15), 4512-4523. [PDF] [Supplementary Data]

  • Boverhof, D.R., Fertuck, K.C., Burgoon, L.D., Eckel, J.E., Gennings, C., Zacharewski, T.R. (2004) Temporal and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol. Carcinogenesis. 25(7), 1277-1291. [PDF] [Supplementary Data]

  • Luyendyk, J.P., Mattes, W.B., Burgoon, L.D., Zacharewski, T.R., Maddox, J.F., Cosma, G.N., Ganey, P.E., Roth, R.A. (2004) Gene Expression Analysis Points to Hemostasis in Livers of Rats Cotreated with Lipopolysaccharide and Ranitidine. Toxicological Sciences. 80, 203-213. [PDF]

  • Yoo, B.S., Boverhof, D.R., Shnaider, D., Crawford, R.B., Zacharewski, T.R., Kaminski, N.E. (2004) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the regulation of Pax5 in lipopolysaccharide-activated B cells. Toxicological Sciences. 77(2), 272-279. [PDF]

 

2003

  • Fertuck, K.C., Eckel, J.E., Gennings, C., Zacharewski, T.R. (2003) Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol. Physiological Genomics. 15(2), 127-141. [PDF] [Supplementary Data]

  • Cunningham, M.L., Bogdanffy, M.S., Zacharewski, T.R., Hines, R.N. (2003) Workshop overview: use of genomic data in risk assessment. Toxicological Sciences. 73(2), 209-215. [PDF]

  • Fielden, M.R., Samy, S.M., Chou, K.C., Zacharewski, T.R. (2003) Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice. Food and Chemical Toxicology. 41(4), 447-454. [PDF]

  • Lash, L.H., Hines, R.N., Gonzalez, F.J., Zacharewski, T.R., Rothstein, M.A. (2003) Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile? The Journal of Pharmacology and Experimental Therapeutics. 305(2), 403-409. [PDF]

 

2002

  • Fielden, M.R., Fertuck, K.C., Matthews, J.B., Halgren, R. and Zacharewski, T (2002) In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Critical Reviews in Toxicology. 32(2), 67-112 [PDF]

  • Fielden, M.R., Halgren, R.G., Dere, E. and Zacharewski, T. (2002) GP3: GenePix post-processing script for the automated analysis of raw microarray image output files. Bioinformatics. 18(5), 771-773. [PDF]

  • Charles, G.D., Gennings, C., Zacharewski, T., Gollapudi B.B. and Carney, E. (2002) An Approach for Assessing Estrogen Receptor-Mediated Interactions in Mixtures of Three Chemicals: A Pilot Study. Toxicological Sciences. 68, 349-360. [PDF]

  • Fielden, M.R., Halgren, R.G., Fong, C.J., Staub, C., Johnson, L., Chou, K. and Zacharewski, T. (2002) Gestational and Lactational Exposure of Male Mice to Diethylstilbestrol Causes Long-Term Effects on the Testis, Sperm Fertilizing Ability in Vitro, and Testicular Gene Expression. Endocrinology. 143(8), 3044-3059. [PDF] [Supplementary Data]

  • Fielden, M.R., Fong, C.J., Haslam, S.Z. and Zacharewski, T. (2002) Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure . Toxicology Letters. 133, 181-191. [PDF]

  • Charles, G.D., Gennings, C., Zacharewski, T., Gollapudi, B.B. and Carney, E.W. (2002) Assessment of Interactions of Diverse Ternary Mixtures in an Estrogen Receptor-α Reporter Assay. Toxicology and Applied Pharmacology. 180, 11-21. [PDF]

  • Rosen, G., O'Bryant, E., Matthews,J., Zacharewski, T. and Wade, J. (2002) Distribution of Androgen Receptor mRNA Expression and Immunoreactivity in the Brain of the Green Anole Lizard. Journal of Neuroendocrinology. 14(1), 19-28. [PDF]

  • Matthews, J.B., K.C. Fertuck, T. Celius, Y.W. Huang, C.J. Fong and T.R. Zacharewski. 2002. Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species. Journal of Steroid Biochemistry and Molecular Biology. 82 (2), 181-194. [PDF]

  • Kavlock, R., Boekelheide, K., Chapin, R., Cunningham, M., Faustman, E., Foster, P., Golub, M., Henderson, Hinberg, I.,Little, R., Seed, J., Shea, K., Tabacova, S., Tyl, R., Williams, P., Zacharewski, T. (2002) NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate. Reproductive Toxicology. 16(5), 721-734.

 

2001

  • Fertuck, K., Matthews, J.B. and Zacharewski, T.R. (2001) Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicological Sciences, 59, 231- 240 [PDF]

  • Fielden, M.R and Zacharewski, T. (2001) Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicological Sciences, 60, 6-10 [PDF]

  • Matthews, J.B., Twomey, K. and Zacharewski, T.R. (2001) In vitro and in vivo interactions of Bisphenol A and Bisphenol A glucuronide, with estrogen receptors and . Chemical Research in Toxicology, 14(2), 149-157 [PDF]

  • Halgren, R.G., Fielden, M.R., Fong, C.J. and Zacharewski, T.R. (2001) Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones. Nucleic Acids Research, 29(2), 582-588 [PDF]
    NOTE - Highlighted in Nature, 410 (April 19). When the chips are down. 860-861. [PDF] [Supplementary Data]

  • Fielden, M.R., Halgren, R.G., Tashiro, C.H.M., Yeo, B.R., Chittim, B., Chou, K. and Zacharewski, T.R. (2001) Effects of gestational and lactational exposure to Aroclor 1242 on testis size and sperm quality in early adult and middle-age mice. Reproductive Toxicology, 15, 281-292 [PDF]

  • Fertuck, K.C., Kumar, S., Sikka, H.C., Matthews, J.B. and Zacharewski, T. (2001) Interaction of PAH-related compounds with the and isoforms of the estrogen receptor. Toxicology Letters, 121, 167-177 [PDF]

  • Matthews, J.B., Clemons, J.H. and Zacharewski, T. (2001) Reciprocal mutagenesis between human (L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Molecular and Cellular Endocrinology, 183(1-2), 167-177 [PDF]

 

2000

  • Matthews, J. and Zacharewski, T.R. (2000) Differential binding affinities of PCBs, HO-PCBs and Aroclors with recombinant human, reptilian (Anolis carolinensis) and rainbow trout (Onchorhynchus mykiss) estrogen receptors using a semi-high throughput competitive receptor binding assay. Toxicological Sciences, 53, 326-339. [PDF]

  • Fielden M.R.,Wu Z.F., Sinal C.J., Hodgert Jury H., Bend J.R., Hammond G, Balaguer P., and Zacharewski T.R. (2000) Estrogen receptor and Ah receptor-mediated activities of a coal-tar creosote. Environmental Chemistry and Toxicology, 19(5), 1262-1271.

  • Charles, G.D., Bartels, M.J., Zacharewski, T., Gallopudi, B.B., Freshour, N.L., and Carney, E.W. (2000) Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor reporter gene assay. Toxicological Sciences. 55(2), 320-326. [PDF]

  • Charles, G.D., Bartels, M.J., Gennings, C., Zacharewski, T., Freshour, N.L., Gallopudi, B.B. and Carney, E.W. (2000) Incorporation of S-9 activation into an estrogen receptor transactivation assay. Reproductive Toxicology. 14, 207-216. [PDF]

  • Charles, G.D., Gennings, C., Clemons, J., Zacharewski, T.R., Gallopudi, B.B. and Carney, E.W. (2000) Optimization of an estrogen receptor a transcriptional activation assay for testing a diverse spectrum of chemicals. Journal of Applied Toxicology, 20, 449-454.

  • Matthews, J.B., Celius, T., Halgren, R. and Zacharewski, T.R. (2000) Differential estrogen receptor binding of estrogenic substances: a comparison across species. Journal of Steroid Biochemistry and Molecular Biology, 74(4), 223-234. [PDF]

  • Hodgert Jury, H., Zacharewski, T.R. and Hammond, G.L. (2000) Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands in the diet and environment. Journal of Steroid Biochemistry and Molecular Biology , 75(2-3), 109-119. [PDF]

  • Celius, T., Matthews, J.B., Villalobos, S.A., Giesy, J.P., and Zacharewski, T.R. (2000) Quantification of rainbow trout (oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with 17 -estradiol and -zearalenol. Journal of Steroid Biochemistry and Molecular Biology , 75(2-3), 109-119 [PDF]

 

1999

  • Gillesby, B.E. and Zacharewski, T. (1999) Determination of pS2 mRNA levels in human breast cancer tumors using quantitative, competitive RT-PCR: correlation with clinical and histological prognostic markers. Breast Cancer Research and Treatment, 56, 253-265. [PDF]
 

1998

  • Gillesby, B.E. and Zacharewski, T. (1998) Endocrine disrupters: mechanisms of action and strategies for identification and assessment. Environmental Toxicology and Chemistry - Annual Review, 17, 3-14.

  • Gould, J.C., Leonard, L.S., Maness, S.C., Wagner, B.L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D.P., and Gaido, K.W. (1998) Bisphenol A interacts with the estrogen receptor in a distinct manner from estradiol. Molecular and Cellular Endocrinology, 142, 203-214. [PDF]

  • Clemons, J.H., Marvin, C.R., Wu, Z.F., McCarry, B.E., Legzdins, A.E., Bryant, D.W. and Zacharewski, T.R. (1998) Identification of estrogen- and dioxin-like activities in urban air particulate material using recombinant receptor/reporter gene bioassays. Environmental Science and Technology, 32, 1853-1860. [PDF] NOTE - Highlighted in Analytical Chemistry (1998) Endocrine Disruptors in the Air, 70, 502A.

  • Desaulniers, D., Leingartner, K., Zacharewski, T. and Foster, W.G. (1998) Optimization of an MCF7-E3 cell proliferation assay and effects of environmental pollutants and industrial chemicals. Toxicology In Vitro, 12, 409-422. [PDF]

  • Twiner, M.J., Hirst, M., Valenciano, A., Zacharewski, T. and Dixon, S.J. (1998) N,N-Dimethylformamide modulates acid extrusion from murine hepatoma cells. Toxicology and Applied Pharmacology, 153, 143-151. [PDF]

  • Zacharewski, T., Meek, M.D., Clemons, J.H., Wu, Z.F., Fielden, M.R. and Matthews, J.B. (1998) Examination of the estrogenic activities of eight commercial phthalate esters. Toxicological Sciences, 46, 282-293.

  • Fail, P.A., Hines, J.W., Zacharewski, T., Wu, Z.F., and Borodinsky, L. (1998) Assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and an in vitro recombinant receptor reporter gene assay. Drug and Chemical Toxicology, 21(Suppl. 1), 101-121.

 

1997

  • Moore, M., Mustain, M., Daniel, K., Chen, I., Safe, S., Zacharewski, T., Gillesby, B., Joyeux, A. and Balaguer, P. (1997) Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicology and Applied Pharmacology, 142, 160-168. [PDF]

  • Zacharewski, T. (1997) In vitro bioassays for assessing estrogenic substances. Environmental Science and Technology, 31, 613-623. [PDF]

  • Gillesby, B., Stanostefano, M., Porter, W., Safe, S., Wu, Z.F. and Zacharewski, T. (1997) Identification of an inhibitory dioxin-like response element (iDRE) required for TCDD-mediated suppression of pS2 expression. Biochemistry, 36, 6080-6089. [PDF]

  • Connor, K., Ramamoorthy, K., Moore, M., Mustain, M., Chen, I., Safe, S., Zacharewski, T., Gillesby, B., Joyeux, A. and Balaguer, P. (1997) Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Toxicology and Applied Pharmacology, 145, 111-123. [PDF]

  • Fielden, M.R., Chen, I., Chittim, B., Safe, S. and Zacharewski, T. (1997) Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB104) and its hydroxylated 2,4,6,2',6'- pentachloro-4-biphenylol (HO-PCB104) and chlorinated, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB155) derivatives. Environmental Health Perspectives, 105, 1238-1248. [HTML]

 

1996

  • Connor, K., Howell, J., Chen, I., Liu, H., Berhane, K., Sciarretta, C., Safe, S. and Zacharewski, T. (1996) Failure of chloro-S-triazine-derived compounds to induce estrogen receptor- mediated responses in vivo and in vitro. Fundamental and Applied Toxicology, 30, 93-101. [PDF]
 

1995

  • Zacharewski, T., Berhane, K., Gillesby, B. and Burnison, B.K. (1995) Evidence for the presence of estrogen receptor and Ah receptor ligands in pulp and paper mill black liquor. Environmental Science and Technology, 29, 2140-2146.

  • Ruh, M.F., Zacharewski, T., Connor, K., Howell, J., Chen, I. and Safe, S. (1995) Naringenin: a weakly estrogenic bioflavonoid which exhibits antiestrogenic activity. Biochemical Pharmacology, 50, 1485-1493.[PDF]

  • Safe, S., Washburn, K., Zacharewski, T. and Phillips, T. (1995) Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum. Chemosphere 31, 3017-3023.

 

1994

  • Zacharewski, T., Bondy, K.L., McDonnell, P. and Wu, Z.F. (1994) Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on 17 -estradiol induced pS2 expression. Cancer Research, 54, 2707-2713.
 

1993

  • Harris, M., Zacharewski, T. and Safe, S. (1993) Comparative potencies of Aroclors 1232, 1242, 1248, 1254 and 1260 in male Wistar rats - assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundamental and Applied Toxicology, 20, 456- 463. [PDF]

  • Heery, D., Zacharewski, T., Pierrat, B. , Gronemeyer, H. , Chambon, P. and Losson, R. (1993) Reconstitution of RA-mediated signal transduction in yeast: the requirement of RAR/RXR heterodimers. Proceedings of the National Academy of Sciences, USA, 90, 4281- 4285. NOTE - Heery and Zacharewski are considered equal first authors.

  • Bondy, K.L. and Zacharewski, T. (1993) ICI 164,384: a control for investigating estrogen responsive genes. Nucleic Acids Research, 21, 5277-5278.

 

1992

  • Zacharewski, T., Harris, M., Biegel, L., Morrison, V., Merchant, M. and Safe, S. (1992) 6-Methyl-1,3,6-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicology and Applied Pharmacology, 113, 311-318.

  • Leid, M., Kastner, P., Lyons, R., Nakshatri, H., Saunders, M., Zacharewski, T., Chen, J., Staub, A., Garnier, J. M. and Chambon, P. (1992) Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to efficiently bind target sequences. Cell, 68, 377-395.

  • Reddy, A. P., Chen, J., Zacharewski, T., Gronemeyer, H., Voorhees, J. J. and Fisher, G. J. (1992) Expression of human retinoic acid receptor in the baculovirus-insect cell expression system. Biochemical Journal, 87, 833-840.

 

In Press

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