Publications

See the full list on Pubmed

2018

Fader, K. A., Nault, R., Raehtz, S., McCabe, L. R., and Zacharewski, T. R. (2018). 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol. PMID: 29673856

2017

Fader, K. A. and Zacharewski, T. R. (2017). Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds. Current Opinions in Toxicology 2, 36-41. PMID: 289428239

Nault, R., Fader, K. A., Harkema, J.R. and Zacharewski, T. R. (2017). Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. PLoS One 12(9). PMID: 28922406

Nault, R., Fader, K. A., Lydic, T. A. and Zacharewski, T. R. (2017). Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Chemical research in toxicology 30(4), 1060-1075. PMID: 28238261

 Fader, K. A., Nault, R., Kirby, M. P., Markous, G., Matthews, J. and Zacharewski, T. R. (2017). Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBalpha/beta activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 321, 1-17. PMID: 28213091

 Stedtfeld, R.D., Stedtfeld, T.M., Fader, K.A., Williams, M.R., Bhaduri, P., Quensen, J., Zacharewski, T. R., Tiedje, J.M., and Hashsham, S.A. (2017). TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome. FEMS Microbiol Ecol 93(5). PMID: 28475713

2016

Nault, R., Fader, K. A., Kopec, A. K., Harkema, J. R., Zacharewski, T. R. and Luyendyk, J. P. (2016). From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis. Toxicol Sci 154(2), 381-391. PMID: 27613713

Nault, R., Fader, K. A., Kirby, M. P., Ahmed, S., Matthews, J., Jones, A. D., Lunt, S. Y. and Zacharewski, T. R. (2016). Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Toxicol Sci 149(2), 358-71. PMID: 26582802 supplementary data

 Nault, R., Fader, K. A., Ammendolia, D. A., Dornbos, P., Potter, D., Sharratt, B., Kumagai, K., Harkema, J. R., Lunt, S. Y., Matthews, J. and Zacharewski, T. (2016). Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis. Toxicol Sci 154(2), 253-266. PMID: 27562557

2015

Nault, R., Fader, K. A. and Zacharewski, T. (2015). RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice. BMC genomics 16(1), 373. PMID: 25958198

 Nault, R., Colbry, D., Brandenberger, C., Harkema, J. R. and Zacharewski, T. R. (2015). Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicol Pathol 43(3), 366-75. PMID: 25274660

Fader, K. A., Nault, R., Ammendolia, D. A., Harkema, J. R., Williams, K. J., Crawford, R. B., Kaminski, N. E., Potter, D., Sharratt, B. and Zacharewski, T. R. (2015). 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicol Sci 148(2), 567-80. PMID: 26377647

 2013

Nault, R., Kim, S. and Zacharewski, T. R. (2013). Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicol Appl Pharmacol 267(2), 184-91. PMID: 23238561

 Nault, R., Forgacs, A. L., Dere, E. and Zacharewski, T. R. (2013). Comparisons of differential gene expression elicited by TCDD, PCB126, betaNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicology letters 223(1), 52-59. PMID: 23994337

Kopec, A. K., Boverhof, D. R., Nault, R., Harkema, J. R., Tashiro, C., Potter, D., Sharratt, B., Chittim, B. and Zacharewski, T. R. (2013). Toxicogenomic Evaluation of Long-term Hepatic Effects of TCDD in Immature, Ovariectomized C57BL/6 Mice. Toxicol Sci 135(2), 465-75. PMID: 23864506

 2012

Kopec, A.K., Thompson, C.M., Kim, S., Forgacs, A.L., and Zacharewski, T. R. (2012). Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. Toxicol Appl Pharmacol 262(2), 124-138. PMID: 22561333  Raw data

Kopec, A.K., Kim, S., Forgacs, A.L., Zacharewski, T.R., Proctor, D.M., Harris, M.A., Haws, L.C., and Thompson, C.M. (2012). Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol 259(1), 13-26. PMID: 22155349 Raw data

2011

Thompson, C.M., Proctor, D.M., Haws, L.C., Hebert, C.D., Grimes, S.D., Shertzer, H.G., Kopec, A.K., Hixon, J.G., Zacharewski, T.R., and Harris, M.A. (2011). Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicol Sci 123(1), 58-70. PMID: 21712504  Raw data