Bioinformatics Group

Who Are We?

The Bioinformatics Group is a team of developers made up of three permanent members (2 grad students and 1 post-doc), and a variable number of undergraduate cooperative education students. Our goal is to provide tools and expertise to our lab and collaborators to assist in the analysis of toxicogenomic data. Our largest project is the development of our toxicogenomic supportive information management and analysis system, the dbZach System. Other projects include the development of tools for the normalization and analysis of genomic data, quality control of cDNA microarrays, the identification of response-elements in promoter and enhancer regions of genes, and gene orthologues across our three species of interest: the human, mouse, and rat. Please see the Personnel section of the site for more information on individual projects and the people working on them.

Guidance Documents

The Zacharewski Bioinformatics Group Guidance documents can be found here. These documents are available to all interested parties. As new versions of these documents are developed and approved, they will be placed on our website.


The Zacharewski Lab Bioinformatics Group started out as a Perl Hack group composed of Dr. Rob Halgren and Lyle Burgoon in the summer of 1999. The original tasks of the group were to remotely access genomic databases to identify ortholgues of genes expressed in mouse testis and the identification of genes expressed in mouse testis.

When the lab began developing cDNA microarrays, the group's focus expanded to include the creation of a cDNA clone-gene annotation database. This database matured into the toxicogenomics supportive database, dbZach. Over time several cooperative education students from several different universities have assisted on the dbZach project. For more information about the dbZach project please see the dbZach site.

Today, the Bioinformatics Group's focus has expanded even further. The group has begun long-term production and support of the dbZach System -- an integrated data mining and analysis suite to complement the dbZach database. Dr. Yan Sun and Lyle Burgoon are both independently working on different artifical intelligence methods for the analysis and prediction of promoter responsive elements. Lyle Burgoon is also continuing to research better statistical methods for analysis and normalization of microarray data.


updated: Wednesday Dec 3, 2003 17:28:26